But the same as nuclear transformation, plastid transformation also has the problems of bio-safety of antibiotic markers and development obstacles due to the overexpression of foreign gene.

但同细胞核转基因一样，叶绿体转基因也存在抗生素标记的生物安全性和外源基因的过量表达对植物正常生长发育的影响的问题。

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While this may seem straightforward enough at a high level, there are many obstacles that frequently arise in typical software development.

从高层次的角度来看，这可能十分简单，但是在典型的软件开发中总会出现许多障碍。

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Indeed, many obstacles may seem to prevent the development team's involvement with customers.

实际上，许多障碍似乎会阻止客户参与开发团队的工作。

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States should cooperate with each other in ensuring development and eliminating obstacles to development.

UNESCO: Vienna Declaration and Programme of Action

The international community should promote an effective international cooperation for the realization of the right to development and the elimination of obstacles to development.

UNESCO: Vienna Declaration and Programme of Action

Saving Lives at Birth is the first in a series of Grand Challenges for Development that will be announced by USAID in the coming years to mobilize focused attention and resources around the most pressing obstacles to achieving our development goals.

WHITEHOUSE: Office of Science and Technology Policy Blog